HAND2 antibody (C-Term)

Catalog No. ABIN927294

Product Details anti-HAND2 Antibody

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAND2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Hand2 antibody was raised in rabbit using the C terminal of Hand2 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Hand2 Blocking Peptide, catalog no. 33R-2133, is also available for use as a blocking control in assays to test for specificity of this Hand2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for HAND2

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Alternative Name: Hand2 (HAND2 Products)

Synonyms: DHAND2 antibody, Hed antibody, Thing2 antibody, bHLHa26 antibody, dHand antibody, dhand2 antibody, hand2 antibody, xhand2 antibody, hand2-b antibody, Hand2' antibody, dHAND antibody, HAND2 antibody, hed antibody, dhand antibody, thing2 antibody, LOC100218345 antibody, AI225906 antibody, AI661148 antibody, Ehand2 antibody, Th2 antibody, zdHAND antibody, zgc:103415 antibody, Hand2 antibody, heart and neural crest derivatives expressed 2 antibody, heart and neural crest derivatives expressed 2 L homeolog antibody, heart and neural crest derivatives expressed 2 S homeolog antibody, HAND2 antibody, Hand2 antibody, hand2.L antibody, hand2.S antibody, hand2 antibody

Background: Hand2 is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. It is required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. It plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Hand2 is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Synonyms: Polyclonal Hand2 antibody, Anti-Hand2 antibody, heart and neural crest derivatives expressed transcript 2 antibody, AI225906 antibody, AI661148 antibody, Ehand2 antibody, Hed antibody, Th2 antibody, Thing2 antibody, bHLHa26 antibody, dHAND antibody.

Pathways: Tube Formation, Feeding Behaviour