TCHP antibody (C-Term)

Catalog No. ABIN926521

Product Details anti-TCHP Antibody

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCHP antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: TCHP antibody was raised in rabbit using the C terminal of TCHP as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TCHP Blocking Peptide, catalog no. 33R-4111, is also available for use as a blocking control in assays to test for specificity of this TCHP antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for TCHP

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Alternative Name: TCHP (TCHP Products)

Synonyms: TpMs antibody, A930031F18Rik antibody, AV279199 antibody, RGD1310813 antibody, zgc:136634 antibody, trichoplein keratin filament binding antibody, trichoplein, keratin filament binding antibody, trichoplein, keratin filament binding L homeolog antibody, TCHP antibody, tchp antibody, Tchp antibody, tchp.L antibody

Background: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Synonyms: Polyclonal TCHP antibody, Anti-TCHP antibody, trichoplein, keratin filament binding antibody, MGC10854 antibody.