Topoisomerase II alpha antibody (C-Term)
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- Target See all Topoisomerase II alpha (TOP2A) Antibodies
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Pig, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Topoisomerase II alpha antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Dog (Canine), Rat (Rattus), Mouse (Murine), Pig (Porcine)
- Immunogen
- TOP2 A antibody was raised in rabbit using the C terminal of TOP2 as the immunogen
- Top Product
- Discover our top product TOP2A Primary Antibody
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- Application Notes
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WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator. - Comment
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TOP2A Blocking Peptide, catalog no. 33R-9809, is also available for use as a blocking control in assays to test for specificity of this TOP2A antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- Target
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
- Alternative Name
- TOP2A (TOP2A Products)
- Synonyms
- TOP2 antibody, TP2A antibody, TOP2A antibody, Top-2 antibody, TOP-2 antibody, F12B17.110 antibody, F12B17_110 antibody, thimet metalloendopeptidase 2 antibody, fc08c07 antibody, wu:fc08c07 antibody, DNA topoisomerase II alpha antibody, DNA topoisomerase II, alpha isozyme antibody, topoisomerase (DNA) II alpha antibody, Zincin-like metalloproteases family protein antibody, TOP2A antibody, Bm1_08705 antibody, Top2a antibody, AT5G10540 antibody, top2a antibody
- Background
- TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. Synonyms: Polyclonal TOP2A antibody, Anti-TOP2A antibody, topoisomerase, DNA II alpha 170kDa antibody.
- Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
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