TIMELESS antibody (N-Term)

Catalog No. ABIN925899

Product Details anti-TIMELESS Antibody

Target: TIMELESS (Timeless Homolog (TIMELESS))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Drosophila melanogaster, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMELESS antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Dog (Canine), Mouse (Murine), Rat (Rattus), Cow (Bovine), Frog, Fruit Fly (Drosophila melanogaster)

Immunogen: TIMELESS antibody was raised in rabbit using the N terminal of TIMELESS as the immunogen

Application Details

Application Notes: WB: 2.5 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TIMELESS Blocking Peptide, catalog no. 33R-5848, is also available for use as a blocking control in assays to test for specificity of this TIMELESS antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Alternative Name: TIMELESS (TIMELESS Products)

Synonyms: TIM antibody, TIM1 antibody, hTIM antibody, C77407 antibody, Debt69 antibody, tim antibody, CG3234 antibody, Dmel\\CG3234 antibody, Ritsu antibody, Tim antibody, dTIM antibody, dTim antibody, dtim antibody, mel_tim antibody, rit antibody, tim1 antibody, XTimeless1 antibody, timeless antibody, timelessb antibody, TIMELESS antibody, MXC20.14 antibody, MXC20_14 antibody, htim antibody, im:6903167 antibody, wu:fa95g04 antibody, wu:fd23d07 antibody, timeless circadian regulator antibody, timeless circadian clock 1 antibody, timeless antibody, timeless circadian clock antibody, timeless circadian clock S homeolog antibody, timeless family protein antibody, TIMELESS antibody, Timeless antibody, tim antibody, timeless.S antibody, Tim antibody, ATIM antibody, timeless antibody, LOC100328917 antibody

Background: The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein. Synonyms: Polyclonal TIMELESS antibody, Anti-TIMELESS antibody, timeless homolog, Drosophila antibody.

Pathways: Protein targeting to Nucleus, Photoperiodism