ZWINT antibody (AA 85-170) (Biotin)

Catalog No. ABIN920497

Product Details anti-ZWINT Antibody (Biotin)

Target: ZWINT (ZW10 Interactor (ZWINT))

Binding Specificity: AA 85-170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZWINT antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZWINT

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ZWINT

Target: ZWINT (ZW10 Interactor (ZWINT))

Alternative Name: ZWINT (ZWINT Products)

Synonyms: ZWINT antibody, HZwint-1 antibody, KNTC2AP antibody, ZWINT1 antibody, 2010007E07Rik antibody, 2600001N01Rik antibody, D10Ertd749e antibody, Zwint-1 antibody, Sip30 antibody, ZW10 interacting kinetochore protein antibody, ZW10 interactor antibody, ZWINT antibody, Zwint antibody

Background:

Synonyms: HZwint1, KNTC 2 AP, KNTC2AP, MGC 117174, MGC117174, ZW10 interacting protein 1, ZW10 interactor, ZWINT 1, ZWINT1, ZWINT-1, ZWINT_HUMAN.

Background: ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis.

Gene ID: 11130