TNIP2 antibody (AA 85-180) (Biotin)

Catalog No. ABIN918183

Product Details anti-TNIP2 Antibody (Biotin)

Target: TNIP2 (TNFAIP3 Interacting Protein 2 (TNIP2))

Binding Specificity: AA 85-180

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIP2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNIP2/ABIN2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TNIP2

Target: TNIP2 (TNFAIP3 Interacting Protein 2 (TNIP2))

Alternative Name: TNIP2 (TNIP2 Products)

Synonyms: MGC83548 antibody, TNIP2 antibody, ABIN2 antibody, FLIP1 antibody, KLIP antibody, 1810020H16Rik antibody, ABIN-2 antibody, AI428870 antibody, TNFAIP3 interacting protein 2 antibody, TNFAIP3 interacting protein 2 L homeolog antibody, TNIP2 antibody, tnip2.L antibody, tnip2 antibody, Tnip2 antibody

Background:

Synonyms: KLIP, ABIN2, FLIP1, TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, Fetal liver LKB1-interacting protein, TNIP2

Background: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response, this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells, promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene ID: 79155

UniProt: Q8NFZ5

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin