CD248 antibody (AA 251-350) (AbBy Fluor® 647)

Catalog No. ABIN917320

Product Details anti-CD248 Antibody (AbBy Fluor® 647)

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Binding Specificity: AA 251-350

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD248 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TEM 1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-CD248 antibody (AbBy Fluor® 647) (ABIN917320)

Farinon, Clarimundo, Pedrazza, Gulko, Zuanazzi, Xavier, de Oliveira: "Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes." in: European journal of pharmacology, Vol. 799, pp. 180-187, (2017) (PubMed).

Clarimundo, Farinon, Pedó, Teixeira, Nör, Gulko, Xavier, de Oliveira: "Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway." in: Peptides, Vol. 95, pp. 57-61, (2017) (PubMed).

Target Details for CD248

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Alternative Name: Tem1/Cd248 (CD248 Products)

Synonyms: CD164L1 antibody, TEM1 antibody, 2610111G01Rik antibody, AI842296 antibody, Cd164l1 antibody, Tem1 antibody, fb96b12 antibody, wu:fb96b12 antibody, zgc:162651 antibody, CD248 molecule antibody, CD248 antigen, endosialin antibody, CD248 molecule, endosialin a antibody, CD248 antibody, Cd248 antibody, cd248a antibody

Background:

Synonyms: TEM1, CD164L1, Endosialin, Tumor endothelial marker 1, CD248

Background: The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment.

Gene ID: 57124

UniProt: Q9HCU0