SRRM1 antibody (AA 21-120) (Biotin)

Catalog No. ABIN916451

Product Details anti-SRRM1 Antibody (Biotin)

Target: SRRM1 (Serine/arginine Repetitive Matrix 1 (SRRM1))

Binding Specificity: AA 21-120

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRRM1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SRRM1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SRRM1

Target: SRRM1 (Serine/arginine Repetitive Matrix 1 (SRRM1))

Alternative Name: SRRM1 (SRRM1 Products)

Synonyms: 160-KD antibody, POP101 antibody, SRM160 antibody, AA407769 antibody, Srm160 antibody, serine and arginine repetitive matrix 1 antibody, serine/arginine repetitive matrix 1 antibody, SRRM1 antibody, Srrm1 antibody

Background:

Synonyms: Ser/Arg related nuclear matrix protein, Ser/Arg-related nuclear matrix protein, Serine/arginine repetitive matrix protein 1, SR related nuclear matrix protein of 160 kDa, SR-related nuclear matrix protein of 160 kDa, SRm160, Srrm1, SRRM1_HUMAN.

Background: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Gene ID: 10250