TMPRSS2 antibody (AA 301-400) (AbBy Fluor® 647)
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- Target See all TMPRSS2 Antibodies
- TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))
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Binding Specificity
- AA 301-400
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TMPRSS2 antibody is conjugated to AbBy Fluor® 647
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TMPRSS2
- Isotype
- IgG
- Top Product
- Discover our top product TMPRSS2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))
- Alternative Name
- TMPRSS2 (TMPRSS2 Products)
- Synonyms
- PP9284 antibody, PRSS10 antibody, D16Ertd61e antibody, transmembrane protease serine 2-like antibody, transmembrane protease, serine 2 antibody, LOC100739411 antibody, TMPRSS2 antibody, Tmprss2 antibody
- Background
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Synonyms: PP9284, PRSS10, Transmembrane protease serine 2, Serine protease 10, TMPRSS2
Background: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
- Gene ID
- 7113
- UniProt
- O15393
- Pathways
- SARS-CoV-2 Protein Interactome
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