HSD17B6 antibody (AA 61-160) (AbBy Fluor® 488)

Catalog No. ABIN901375

Product Details anti-HSD17B6 Antibody (AbBy Fluor® 488)

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Binding Specificity: AA 61-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B6 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSD17B6

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HSD17B6

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Alternative Name: HSD17B6 (HSD17B6 Products)

Synonyms: HSE antibody, RODH antibody, SDR9C6 antibody, 17betaHSD9 antibody, Hsd17b9 antibody, Rdh8 antibody, hydroxysteroid 17-beta dehydrogenase 6 antibody, hydroxysteroid (17-beta) dehydrogenase 6 antibody, HSD17B6 antibody, Hsd17b6 antibody

Background:

Synonyms: 17-beta-HSD 6, 17-beta-HSD6, 17-beta-hydroxysteroid dehydrogenase type 6, 3 hydroxysteroid epimerase, 3alpha >beta hydroxysteroid epimerase, 3alpha >beta hydroxysteroid epimerasel, 3-alpha->beta-HSE, 3-alpha->beta-hydroxysteroid epimerase, H17B6_HUMAN, HSD17B6, HSE, Hydroxysteroid 17 beta dehydrogenase 6, Hydroxysteroid 17 beta dehydrogenase 6 homolog mouse, Hydroxysteroid 17 beta dehydrogenase 6, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase, Oxidative 3 alpha hydroxysteroid dehydrogenase, Oxidative 3-alpha hydroxysteroid dehydrogenase, Oxidoreductase, Retinol dehydrogenase, RODH, SDR9C6,Short chain dehydrogenase/reductase family 9C, member 6.

Background: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity, Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities, Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Gene ID: 8630

Pathways: Steroid Hormone Biosynthesis