GIMAP5 antibody (AA 101-200) (Biotin)

Catalog No. ABIN898867

Product Details anti-GIMAP5 Antibody (Biotin)

Target: GIMAP5 (GTPase, IMAP Family Member 5 (GIMAP5))

Binding Specificity: AA 101-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIMAP5 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GIMAP5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GIMAP5

Target: GIMAP5 (GTPase, IMAP Family Member 5 (GIMAP5))

Alternative Name: GIMAP5 (GIMAP5 Products)

Synonyms: HIMAP3 antibody, IAN-5 antibody, IAN4 antibody, IAN4L1 antibody, IAN5 antibody, IMAP3 antibody, IROD antibody, Ian4l1 antibody, Ian5 antibody, D630024P16 antibody, E230026N22Rik antibody, GTPase, IMAP family member 5 antibody, GTPase IMAP family member 5 antibody, GIMAP5 antibody, Gimap5 antibody, LOC463896 antibody

Background:

Synonyms: HIMAP3, IAN4, IAN4L1, IAN5, IMAP3, FLJ11296, GIMAP 5, GTPase IMAP family member 5, GTPase, IMAP family member 5, immunity-associated nucleotide 5, hIAN5, IAN 5, Immune associated nucleotide 4 like 1, Immunity associated nucleotide 4 like 1 protein, Immunity associated protein 3, GIMA5_HUMAN.

Background: GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.

Gene ID: 55340

UniProt: Q96F15

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response