GTPase, IMAP Family Member 3 Pseudogene (GIMAP3P) (AA 1-100) antibody (HRP)

Catalog No. ABIN898830

Product Details

Target: GTPase, IMAP Family Member 3 Pseudogene (GIMAP3P)

Binding Specificity: AA 1-100

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse GIMAP3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: GTPase, IMAP Family Member 3 Pseudogene (GIMAP3P)

Alternative Name: GIMAP3 (GIMAP3P Products)

Synonyms: GIMAP3 antibody, IAN4P antibody, GTPase, IMAP family member 3 pseudogene antibody, GIMAP3P antibody

Background:

Synonyms: GTPase, IMAP family member 3 pseudogene, Ian4, Gimap5, 2010110D23Rik, GIMAP 3, GIMAP3, GTPase IMAP family member 3, GTPase of the immune associated protein 3, Immune associated nucleotide 4, Immunity associated nucleotide 4 protein.

Background: GIMAP3p is a murine mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins. The human GIMAP (GTPase of the immunity-associated protein) gene family includes seven functional members residing on (human) chromosome 7q36.1 and one pseudogene (hGIMAP3).