FRMD8 antibody (AA 65-170) (Cy7)

Catalog No. ABIN897835

Product Details anti-FRMD8 Antibody (Cy7)

Target: FRMD8 (FERM Domain Containing 8 (FRMD8))

Binding Specificity: AA 65-170

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRMD8 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FRMD8

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FRMD8

Target: FRMD8 (FERM Domain Containing 8 (FRMD8))

Alternative Name: FRMD8 (FRMD8 Products)

Synonyms: 1200004M23Rik antibody, 2310035N23Rik antibody, 4931429L16Rik antibody, AU018809 antibody, RGD1310323 antibody, FERM domain containing 8 antibody, FERM domain containing 8 L homeolog antibody, FRMD8 antibody, Frmd8 antibody, frmd8.L antibody

Background:

Synonyms: FERM domain containing protein 8, FKSG44, FRMD8_HUMAN.

Background: FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD8 (FERM domain-containing protein 8), also known as FKSG44, is a 464 amino acid protein containing one FERM domain. Existing as two alternatively spliced isoforms, the gene encoding FRMD8 maps to human chromosome 11q13.1. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4 % of human genomic DNA and is considered a gene and disease association dense chromosome. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

Gene ID: 83786