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ETHE1 antibody (AA 191-254) (Biotin)

ETHE1 Reactivity: Human ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN895785
  • Target See all ETHE1 Antibodies
    ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))
    Binding Specificity
    • 14
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 191-254
    Reactivity
    • 41
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 39
    • 2
    Rabbit
    Clonality
    • 41
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ETHE1 antibody is conjugated to Biotin
    Application
    • 16
    • 13
    • 13
    • 9
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human E1
    Isotype
    IgG
    Top Product
    Discover our top product ETHE1 Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))
    Alternative Name
    ETHE1 (ETHE1 Products)
    Synonyms
    zgc:85680 antibody, HSCO antibody, YF13H12 antibody, 0610025L15Rik antibody, Hsco antibody, ETHE1, persulfide dioxygenase antibody, ethylmalonic encephalopathy 1 antibody, Ethe1 antibody, ethe1 antibody, ETHE1 antibody
    Background

    Synonyms: mitochondrial, Ethe1, ETHE1 protein, mitochondrial precursor, ETHE1_HUMAN, ethylmalonic encephalopathy 1, Ethylmalonic encephalopathy protein 1, hepatoma subtracted clone one, Hepatoma subtracted clone one protein, HSCO, Protein ETHE1, YF13H12.

    Background: Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53-induced apoptosis by preventing nuclear localization of RELA.Involvement in disease:Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE) . EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria.

    Gene ID
    23474
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