DEDD2 antibody (AA 201-300) (Biotin)

Catalog No. ABIN893827

Product Details anti-DEDD2 Antibody (Biotin)

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Binding Specificity: AA 201-300

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEDD2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DEDD2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DEDD2

Target: DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Alternative Name: DEDD2 (DEDD2 Products)

Synonyms: FLAME-3 antibody, MGC145883 antibody, 2410050E11Rik antibody, DEDD2 antibody, death effector domain containing 2 antibody, death effector domain containing 2 L homeolog antibody, death effector domain-containing DNA binding protein 2 antibody, DEDD2 antibody, dedd2.L antibody, dedd2 antibody, Dedd2 antibody

Background:

Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,

Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

Gene ID: 162989