COMMD10 antibody (AA 91-190) (HRP)

Catalog No. ABIN891788

Product Details anti-COMMD10 Antibody (HRP)

Target: COMMD10 (COMM Domain Containing 10 (COMMD10))

Binding Specificity: AA 91-190

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMMD10 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COMMD10

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COMMD10

Target: COMMD10 (COMM Domain Containing 10 (COMMD10))

Alternative Name: COMMD10 (COMMD10 Products)

Synonyms: MGC137858 antibody, MGC154437 antibody, PTD002 antibody, 2310003A05Rik antibody, AU019438 antibody, DRWMS2 antibody, COMM domain containing 10 antibody, COMM domain containing 10 L homeolog antibody, COMMD10 antibody, commd10 antibody, commd10.L antibody, Commd10 antibody

Background:

Synonyms: COMM domain containing 10, COMMD 10, FLJ11285, HGNC:30201, HSPC305, PTD002.

Background: COMMD or COMM is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms and define a novel family of structural and functional homologs of MURR1. The prototype of this family, MURR1/COMMD1, suppresses NFkB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs, rather, it functions in the nucleus by affecting the association of NF-kappaB with chromatin.

Gene ID: 51397