CLASP2 antibody (AA 1201-1294) (Biotin)

Catalog No. ABIN891144

Product Details anti-CLASP2 Antibody (Biotin)

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Binding Specificity: AA 1201-1294

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLASP2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLASP2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Alternative Name: CLASP2 (CLASP2 Products)

Background:

Synonyms: CLASP 2, CLIP associating protein 2, Cytoplasmic linker associated protein 2, hOrbit2, KIAA0627, Multiple asters Mast like homolog 2, Protein Orbit homolog 2, CLAP2_HUMAN.

Background: CLASP2 is a microtubule plus end tracking protein that promotes the stabilization of dynamic microtubules and is required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. CLASP2 may act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3 kinase signaling. CLASP2 also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Gene ID: 23122

Pathways: Microtubule Dynamics, Maintenance of Protein Location