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Complement C3c antibody (AA 1051-1200)

C3C Reactivity: Human, Rat, Pig ELISA, WB, ICC, IHC (fro), IHC (p), IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN873279
  • Target See all Complement C3c (C3C) products
    Complement C3c (C3C) (Complement Component C3c (C3C))
    Binding Specificity
    • 14
    • 3
    • 2
    AA 1051-1200
    Reactivity
    • 60
    • 27
    • 16
    • 15
    • 14
    • 12
    • 5
    • 4
    • 3
    • 1
    Human, Rat, Pig
    Host
    • 71
    • 26
    • 10
    • 9
    • 2
    • 2
    Rabbit
    Clonality
    • 114
    • 4
    Polyclonal
    Conjugate
    • 36
    • 34
    • 16
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complement C3c antibody is un-conjugated
    Application
    • 70
    • 51
    • 32
    • 30
    • 26
    • 19
    • 13
    • 13
    • 12
    • 12
    • 11
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Pig, Rat
    Predicted Reactivity
    Mouse,Dog
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Complement C3c alpha' chain fragment 1
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Vass, Süveges, Érces, Nógrády, Varga, Földesi, Futakuchi, Imai, Okada, Okada, Boros, Kaszaki: "Inflammatory activation after experimental cardiac tamponade." in: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 51, Issue 1-2, pp. 1-13, (2013) (PubMed).

  • Target
    Complement C3c (C3C) (Complement Component C3c (C3C))
    Alternative Name
    Complement Fragment 3c (C3C Products)
    Background

    Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

    Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

    Gene ID
    718
    UniProt
    P01024
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