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SHoc2/Sur8 antibody (AA 36-120)

SHOC2 Reactivity: Human, Mouse, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN873061
  • Target See all SHoc2/Sur8 (SHOC2) Antibodies
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Binding Specificity
    • 14
    • 13
    • 10
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 36-120
    Reactivity
    • 41
    • 27
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 41
    Rabbit
    Clonality
    • 41
    Polyclonal
    Conjugate
    • 13
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHoc2/Sur8 antibody is un-conjugated
    Application
    • 37
    • 18
    • 12
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Sheep,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SHOC2/Sur8
    Isotype
    IgG
    Top Product
    Discover our top product SHOC2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Alternative Name
    SHOC2 (SHOC2 Products)
    Synonyms
    AU017287 antibody, Sur8 antibody, mKIAA0862 antibody, SIAA0862 antibody, SOC2 antibody, SUR8 antibody, si:ch211-159c12.3 antibody, si:ch211-197i12.3 antibody, zgc:152956 antibody, soc-2 (suppressor of clear) homolog (C. elegans) antibody, SHOC2 leucine-rich repeat scaffold protein antibody, SHOC2 leucine-rich repeat scaffold protein S homeolog antibody, SHOC2, leucine rich repeat scaffold protein antibody, Shoc2 antibody, shoc2.S antibody, SHOC2 antibody, shoc2 antibody
    Background

    Synonyms: Leucine-rich repeat protein SHOC-2, Leucine-rich repeat protein SHOC-2, Ras-binding protein Sur-8, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein Sur-8 homolog, SHOC2, SHOC2_HUMAN.

    Background: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

    Gene ID
    8036
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