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CCDC98 antibody (AA 51-150)

FAM175A Reactivity: Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN872878
  • Target See all CCDC98 (FAM175A) Antibodies
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Binding Specificity
    • 14
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    AA 51-150
    Reactivity
    • 24
    • 18
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 36
    • 3
    Rabbit
    Clonality
    • 36
    • 3
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCDC98 antibody is un-conjugated
    Application
    • 30
    • 12
    • 12
    • 12
    • 10
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CCDC98
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Alternative Name
    CCDC98 (FAM175A Products)
    Background

    Synonyms: ABRA1, CCDC98, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A, FAM175A, UNQ496/PRO1013

    Background: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

    Gene ID
    84142
    UniProt
    Q6UWZ7
    Pathways
    DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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