ARRDC3 antibody (AA 178-215)

Catalog No. ABIN872868

Product Details anti-ARRDC3 Antibody

Target: ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))

Binding Specificity: AA 178-215

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARRDC3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARRDC3 corresponding to amino acids 178-215.

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ARRDC3

Target: ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))

Alternative Name: ARRDC3 (ARRDC3 Products)

Synonyms: TLIMP antibody, AI450344 antibody, mKIAA1376 antibody, LRRGT00048 antibody, ARRDC3 antibody, arrdc3 antibody, si:dkey-172m14.3 antibody, wu:fc21e01 antibody, zgc:136956 antibody, MGC131006 antibody, DKFZp469D0714 antibody, zgc:92034 antibody, arrestin domain containing 3 antibody, arrestin domain containing 3a antibody, arrestin domain containing 3 S homeolog antibody, arrestin domain containing 3b antibody, ARRDC3 antibody, Arrdc3 antibody, arrdc3 antibody, arrdc3a antibody, arrdc3.S antibody, arrdc3b antibody

Background:

Synonyms: ARRDC 3, Arrestin domain containing protein 3, KIAA1376, Thioredoxin binding protein 2 like inducible membrane, TLIMP, ARRD3_HUMAN.

Background: The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.

Gene ID: 57561