FAM21C antibody (AA 1201-1318)

Catalog No. ABIN872706

Product Details anti-FAM21C Antibody

Target: FAM21C (Family with Sequence Similarity 21, Member C (FAM21C))

Binding Specificity: AA 1201-1318

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM21C antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM21C

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FAM21C

Target: FAM21C (Family with Sequence Similarity 21, Member C (FAM21C))

Alternative Name: Fam21c (FAM21C Products)

Synonyms: Fam21 antibody, NP61201 antibody, FAM21A antibody, VPEF antibody, A130095H06 antibody, C530005J20Rik antibody, D6Wsu116e antibody, fam21c antibody, wu:fb78c06 antibody, zgc:153646 antibody, WASH complex subunit 2C antibody, WASH complex subunit 2 antibody, family with sequence similarity 21, member C antibody, Washc2c antibody, WASHC2C antibody, Washc2 antibody, washc2c antibody

Background:

Synonyms: FAM21A, Family with sequence similarity 21 member C, Hypothetical protein LOC253725, KIAA0592, Protein FAM21C, FA21C_HUMAN.

Background: Playing a essential role in the fission of tubules that serve as transport intermediates during endosome sorting, the WASH complex is present at the surface of endosomes and functions to recruit and activate the Arp2/3 complex for induction of actin polymerization. FAM21, Putative WASH complex subunit FAM21, is a component of the WASH complex. Having undergone evolutionary duplication, four highly homologous family members exist including FAM21A, FAM21B, FAM21C and FAM21D. FAM21 links the WASH complex to endosomes and is required for WASM-dependent retromer-mediated sorting. Also, by directly interacting with CapZ, FAM21 inhibits its anti-capping activity, thereby regulating actin dynamics.

Gene ID: 253725