FAIM2 antibody (AA 211-316)

Catalog No. ABIN872627

Product Details anti-FAIM2 Antibody

Target: FAIM2 (Fas Apoptotic Inhibitory Molecule 2 (FAIM2))

Binding Specificity: AA 211-316

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Pig,Horse,Chicken,Rabbit,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAIM2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FAIM2

Target: FAIM2 (Fas Apoptotic Inhibitory Molecule 2 (FAIM2))

Alternative Name: FAIM2 (FAIM2 Products)

Synonyms: FAIM2 antibody, faim2 antibody, MGC84041 antibody, zgc:110143 antibody, MGC146456 antibody, LFG antibody, LFG2 antibody, NGP35 antibody, NMP35 antibody, TMBIM2 antibody, 2900002L20Rik antibody, Lfg antibody, Lfg2 antibody, NMP25 antibody, Nmp35 antibody, Fas apoptotic inhibitory molecule 2 antibody, Fas apoptotic inhibitory molecule 2 L homeolog antibody, Fas apoptotic inhibitory molecule 2a antibody, fas apoptotic inhibitory molecule 2 antibody, FAIM2 antibody, faim2 antibody, faim2.L antibody, faim2a antibody, CpipJ_CPIJ015441 antibody, Faim2 antibody

Background:

Synonyms: FAIM 2, Fas apoptotic inhibitory molecule 2, LFG, Leguard, Neural membrane protein 35, NGP 35, NGP35, NMP 35, NMP35, Protein leguard, TMBIM 2, TMBIM2, Transmembrane BAX inhibitor mot containing 2, Transmembrane BAX inhibitor mot containing protein 2, LFG2_HUMAN.

Background: Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

Gene ID: 23017