IER3 antibody (AA 85-156)

Catalog No. ABIN872466

Product Details anti-IER3 Antibody

Target: IER3 (Immediate Early Response 3 (IER3))

Binding Specificity: AA 85-156

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IER3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IEX1/Differentiation dependent gene 2 protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for IER3

Target: IER3 (Immediate Early Response 3 (IER3))

Alternative Name: IEX1 (IER3 Products)

Synonyms: DIF-2 antibody, DIF2 antibody, GLY96 antibody, IEX-1 antibody, IEX-1L antibody, IEX1 antibody, PRG1 antibody, AI663993 antibody, cI-3 antibody, gly96 antibody, IER3 antibody, Dif2 antibody, Iex1 antibody, Ler3 antibody, Prg1 antibody, immediate early response 3 antibody, IER3 antibody, Ier3 antibody

Background:

Synonyms: DIF2, IEX1, PRG1, DIF-2, GLY96, IEX-1, IEX-1L, Radiation-inducible immediate-early gene IEX-1, Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1, IER3

Background: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Gene ID: 8870

UniProt: P46695

Pathways: Regulation of Carbohydrate Metabolic Process