FAM33A antibody (AA 2-88)
-
- Target See all FAM33A Antibodies
- FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
-
Binding Specificity
- AA 2-88
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This FAM33A antibody is un-conjugated
- Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SKA2
- Isotype
- IgG
- Top Product
- Discover our top product FAM33A Primary Antibody
-
-
- Application Notes
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
-
- Target
- FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
- Alternative Name
- SKA2 (FAM33A Products)
- Synonyms
- FAM33A antibody, 1110001A07Rik antibody, C78640 antibody, Fam33a antibody, RGD1307084 antibody, fam33a antibody, spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore-associated protein 2 antibody, SKA2 antibody, Ska2 antibody, ska2 antibody
- Background
-
Synonyms: FAM33A, Family with sequence similarity 33, member A, FLJ12758, MGC110975, Protein FAM33A, SKA 2, SKA2, SKA2_HUMAN, Spindle and kinetochore associated complex subunit 2, Spindle and kinetochore associated protein 2, Spindle and kinetochore-associated protein 2, Spindle and KT kinetochore associated 2, Spindle and KT associated 2.
Background: Ska2 (spindle and kinetochore associated complex subunit 2), also known as FAM33A, is a 121 amino acid component of the Ska1 complex, a microtubule-binding subcomplex of the outer kinetochore that is critical for proper chromosome segregation. The Ska1 complex is a component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. Localized to the outer kinetochore and spindle microtubules during cell proliferation, Ska2 is essential for spindle checkpoint silencing and exit from mitosis. Downregulation of Ska2 leads to delayed recruitment of MAD2, a component of the mitotic spindle checkpoint, to several kinetochores resulting in occasional loss of individual chromosomes from the metaphase plate. Ska2 is encoded by a gene located on human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes.
- Pathways
- M Phase
-