NLRP12 antibody (AA 176-270)

Catalog No. ABIN872372

Product Details anti-NLRP12 Antibody

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Binding Specificity: AA 176-270

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NALP12

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NALP12 (NLRP12 Products)

Synonyms: Nalp12 antibody, NALP12 antibody, CLR19.3 antibody, FCAS2 antibody, PAN6 antibody, PYPAF7 antibody, RNO antibody, RNO2 antibody, NLR family, pyrin domain containing 12 antibody, NLR family pyrin domain containing 12 antibody, NACHT, LRR and PYD domains-containing protein 3 antibody, Nlrp12 antibody, NLRP12 antibody, LOC100018508 antibody

Background:

Synonyms: CLR19.3, FCAS2, Monarch 1, Monarch-1, NACHT, leucine rich repeat and PYD containing 12, NACHT, LRR and PYD containing protein 12, NACHT, LRR and PYD domains-containing protein 12, NAL12_HUMAN, NLR family, pyrin domain containing 12, NLRP12, Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12, PAN6, PYPAF7, PYRIN containing APAF1 like protein 7, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, RNO, RNO2.

Background: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Gene ID: 91662

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome