The antibody detects endogenous levels of Ephrin-B2 only when phosphorylated at tyrosine 316.
Purification
Affinity purified
Immunogen
Peptide sequence around phosphorylation site of pTyr316 (P-V-Y (p) -I-V) derived from Human Ephrin-B2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.