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Seladin 1 antibody (Biotin)

DHCR24 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN801365
  • Target See all Seladin 1 (DHCR24) Antibodies
    Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))
    Reactivity
    • 43
    • 35
    • 26
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 41
    • 2
    Rabbit
    Clonality
    • 43
    Polyclonal
    Conjugate
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Seladin 1 antibody is conjugated to Biotin
    Application
    • 31
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse, Pig, Rat
    Predicted Reactivity
    Human,Dog,Cow,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Seladin 1
    Isotype
    IgG
    Top Product
    Discover our top product DHCR24 Primary Antibody
  • Application Notes
    WB 1:100-1000
    IHC-P 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))
    Alternative Name
    Seladin 1 (DHCR24 Products)
    Synonyms
    MGC82737 antibody, zgc:101638 antibody, DCE antibody, Nbla03646 antibody, SELADIN1 antibody, seladin-1 antibody, 2310076D10Rik antibody, 5830417J06Rik antibody, mKIAA0018 antibody, 24-dehydrocholesterol reductase antibody, 24-dehydrocholesterol reductase S homeolog antibody, delta(24)-sterol reductase antibody, DHCR24 antibody, dhcr24.S antibody, dhcr24 antibody, LOC5575872 antibody, CpipJ_CPIJ000670 antibody, Dhcr24 antibody
    Background

    Synonyms: Seladin1, Seladin-1, DHCR24, 24 dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, DCE, Desmosterol to cholesterol enzyme, Diminuto dwarf1 homolog, SELADIN1, Selective AD indicator 1, Selective Alzheimer's Disease Indicator 1.

    Background: Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).

    Gene ID
    1718
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