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PDGFRA antibody (AA 1035-1053)
PDGFRA
Reactivity: Human, Mouse, Rat, Chicken, Xenopus laevis
WB, IHC (p), IP
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PDGFRA Antibody
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Target
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PDGFRA
(Platelet Derived Growth Factor Receptor alpha (PDGFRA))
Binding Specificity
All epitopes for PDGFRA antibodies
AA 1035-1053
Reactivity
All reactivities for PDGFRA antibodies
Human, Mouse, Rat, Chicken, Xenopus laevis
Host
All hosts for PDGFRA antibodies
Rabbit
Clonality
All clonalities for PDGFRA antibodies
Polyclonal
Conjugate
All conjugates for PDGFRA antibodies
This PDGFRA antibody is un-conjugated
Application
All applications for PDGFRA antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
Sequence
C-GKRNRHSSQT SEESAIETG Remarks: Antigen Modificati on: Amino acids 1035-1053
Specificity
Recognizes Human PDGF Receptor Type A, doublet, Mr 150/170 kDa.
Cross-Reactivity (Details)
Species reactivity (expected):Chicken, Frog, Mouse, Rat, Zebrafish. Species reactivity (tested):Human.
Purification
Immunoaffinity Chromatography
Immunogen
Synthetic peptide KLH-conjugated corresponding to amino acids 1035-1053 of Human PDGF.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
0.2 M Tris-Glycine, pH 7.4 containing 0.12 M Sodium Chloride and 0.05 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze-thaw cycles.
Target Details for PDGFRA
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Target
PDGFRA
(Platelet Derived Growth Factor Receptor alpha (PDGFRA))
Alternative Name
CD140a / PDGFRA (PDGFRA Products )
Synonyms
AI115593 antibody, CD140a antibody, Pdgfr-2 antibody, APDGFR antibody, PDGFACE antibody, CD140A antibody, PDGFR-2 antibody, PDGFR2 antibody, RHEPDGFRA antibody, PDGFR antibody, PDGFR-A antibody, platelet derived growth factor receptor alpha antibody, platelet derived growth factor receptor, alpha polypeptide antibody, platelet-derived growth factor receptor, alpha polypeptide L homeolog antibody, platelet-derived growth factor receptor, alpha polypeptide antibody, PDGFRA antibody, Pdgfra antibody, pdgfra.L antibody
Background
Platelet-derived Growth Factor Receptor Alpha (PDGFR alpha), a member of the a PDGF Receptor tyrosine kinase family, is a mediator of the biological actions of platelet-derived growth factor (PDGF). PDGF binding to PDGF receptors result in stimulation of cell growth, chemotaxis, and cell shape changes. Unlike PDGFR beta, PDGFR alpha can bind to both PDGF subunits. PDGFR alpha has been implicated in the development of spina bifida. In various mouse models, deregulated PDGFR alpha expression was found to result in congenital neural tube defects. In humans, various PDGFRA promoter haplotypes have been associated with neural tube defects.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
Gene ID
5156
NCBI Accession
NP_006197
Pathways
RTK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Platelet-derived growth Factor Receptor Signaling
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