RGS4 antibody (AA 1-188)

Catalog No. ABIN783994

Product Details anti-RGS4 Antibody

Target: RGS4 (Regulator of G-Protein Signaling 4 (RGS4))

Binding Specificity: AA 1-188

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Sheep, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes RGS4

Cross-Reactivity (Details): Species reactivity (expected):Cow (97 %), Rat (97 %), Rabbit (96 %), Pig (96 %), Sheep (97 %)Species reactivity (tested):Human, Mouse.

Purification: Antigen-Affinity Chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 188 of Human RGS4

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.43 mg/mL

Buffer: 0.1 M Tris, 0.1 M Glycine, 20 % Glycerol ( pH 7) containing 0.01 % Thimerosal as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C.

Target Details for RGS4

Target: RGS4 (Regulator of G-Protein Signaling 4 (RGS4))

Alternative Name: RGS4 (RGS4 Products)

Synonyms: RGP4 antibody, SCZD9 antibody, AA004315 antibody, AA597169 antibody, ESTM48 antibody, ESTM50 antibody, regulator of G protein signaling 4 antibody, regulator of G-protein signaling 4 antibody, RGS4 antibody, Rgs4 antibody

Background: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37 % identical to RGS1 and 97 % identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]Synonyms: RGP4, Regulator of G-protein signaling 4

Gene ID: 5999

NCBI Accession: NP_005604

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling