PKDCC antibody (Center)

Catalog No. ABIN783833

Product Details anti-PKDCC Antibody

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKDCC antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography

Immunogen: 15 amino acid peptide from near the center of human VLK.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

References for anti-PKDCC antibody (ABIN783833)

Maddala, Skiba, Rao: "Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells." in: Journal of cellular physiology, Vol. 232, Issue 9, pp. 2447-2460, (2017) (PubMed).

Bordoli, Yum, Breitkopf, Thon, Italiano, Xiao, Worby, Wong, Lin, Edenius, Keller, Asara, Dixon, Yeo, Whitman: "A secreted tyrosine kinase acts in the extracellular environment." in: Cell, Vol. 158, Issue 5, pp. 1033-44, (2014) (PubMed).

Target Details for PKDCC

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Alternative Name: PKDCC (PKDCC Products)

Synonyms: SGK493 antibody, Vlk antibody, AI115348 antibody, AW548124 antibody, Adtk1 antibody, ESTM17 antibody, MAd1 antibody, Sgk493 antibody, X83346 antibody, RGD1311939 antibody, protein kinase domain containing, cytoplasmic antibody, PKDCC antibody, Pkdcc antibody

Background: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.Synonyms: LOC91461, Protein kinase domain-containing protein, Protein kinase-like protein SgK493, Sugen kinase 493, VLK, Vertebrate lonesome kinase

Gene ID: 91461

NCBI Accession: NP_612379

UniProt: Q504Y2