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ASAH1 antibody (C-Term)

ASAH1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783822
  • Target See all ASAH1 Antibodies
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Binding Specificity
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 28
    • 21
    • 5
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 39
    • 4
    Rabbit
    Clonality
    • 39
    • 4
    Polyclonal
    Conjugate
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASAH1 antibody is un-conjugated
    Application
    • 32
    • 14
    • 13
    • 13
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Acid ceramidase at C-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid peptide near the carboxy terminus of the Human ASAH1
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    Discover our top product ASAH1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as presrevative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C up to three months or (in aliquots) at -20 °C for longer.
  • Target
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Alternative Name
    Acid Ceramidase (ASAH1 Products)
    Synonyms
    AC antibody, ACDase antibody, ASAH antibody, PHP antibody, PHP32 antibody, SMAPME antibody, 2310081N20Rik antibody, Asah antibody, MGC82286 antibody, asah1 antibody, zgc:101637 antibody, ASAH1 antibody, zgc:66026 antibody, N-acylsphingosine amidohydrolase 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1a antibody, Acid ceramidase antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1b antibody, ASAH1 antibody, Asah1 antibody, asah1.L antibody, asah1a antibody, asah-1 antibody, asah1b antibody
    Background
    Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.Synonyms: ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein
    Gene ID
    427
    NCBI Accession
    NP_001120977
    UniProt
    Q13510
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