CXXC4 antibody (N-Term)
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- Target See all CXXC4 Antibodies
- CXXC4 (CXXC Finger Protein 4 (CXXC4))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CXXC4 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects CXXC4 at N-term.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 18 amino acid peptide near the amino terminus of human CXXC4
- Top Product
- Discover our top product CXXC4 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- Target
- CXXC4 (CXXC Finger Protein 4 (CXXC4))
- Alternative Name
- CXXC4 (CXXC4 Products)
- Synonyms
- 9330210J02Rik antibody, C030003J12Rik antibody, Idax antibody, IDAX antibody, Xldax antibody, xIdax antibody, CXXC finger 4 antibody, CXXC finger protein 4 antibody, CXXC finger protein 4 S homeolog antibody, Cxxc4 antibody, CXXC4 antibody, cxxc4.S antibody
- Background
- CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
- Gene ID
- 80319
- NCBI Accession
- NP_079488
- UniProt
- Q9H2H0
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