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NALP8 antibody (N-Term)

NLRP8 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783713
  • Target See all NALP8 (NLRP8) Antibodies
    NALP8 (NLRP8) (NLR Family, Pyrin Domain Containing 8 (NLRP8))
    Binding Specificity
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    Human
    Host
    • 2
    • 1
    Rabbit
    Clonality
    • 3
    Polyclonal
    Conjugate
    • 3
    This NALP8 antibody is un-conjugated
    Application
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects NALP8 at N-term. This antibody is predicted to not cross-react with other NALP family members.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography purified via peptide column
    Immunogen
    16 amino acid peptide near the amino terminus of Human NALP8
    Top Product
    Discover our top product NLRP8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    NALP8 (NLRP8) (NLR Family, Pyrin Domain Containing 8 (NLRP8))
    Alternative Name
    NALP8 (NLRP8 Products)
    Synonyms
    CLR19.2 antibody, NALP8 antibody, NOD16 antibody, PAN4 antibody, NLR family pyrin domain containing 8 antibody, NLRP8 antibody
    Background
    NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP8 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It maps to chromosome 19q13.42 and is thought to be expressed in testis and ovary, suggesting that NALP8 may be involved in reproduction. Surprisingly, NALP8 seems to be universal in mammals except for rodents, suggesting that the gene may have been lost during evolution.Synonyms: LRR and PYD domains-containing protein 8, NACHT, NLRP8, NOD16, PAN4, PYRIN and NACHT-containing protein 4
    Gene ID
    126205
    NCBI Accession
    NP_789781
    UniProt
    Q86W28
    Pathways
    Inflammasome
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