NLRP5 antibody (C-Term)

Catalog No. ABIN783707

Product Details anti-NLRP5 Antibody

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects NLRP5 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of human NALP5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for NLRP5

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Alternative Name: NLRP5 (NLRP5 Products)

Synonyms: CLR19.8 antibody, MATER antibody, NALP5 antibody, PAN11 antibody, PYPAF8 antibody, Mater antibody, Nalp5 antibody, Op1 antibody, NLR family pyrin domain containing 5 antibody, NLR family, pyrin domain containing 5 antibody, NLRP5 antibody, Nlrp5 antibody

Background: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.Synonyms: LRR and PYD domains-containing protein 5, MATER, NALP5

Gene ID: 126206

NCBI Accession: NP_703148

UniProt: P59047

Pathways: Inflammasome