FREM2 antibody (Center)

Catalog No. ABIN783636

Product Details anti-FREM2 Antibody

Target: FREM2 (Fras1 Related Extracellular Matrix Protein 2 (FREM2))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FREM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts with Human and Mouse FREM2 and is predicted to not cross-react with other FRAS members. This antibody recognizes both isoforms of FREM2.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center of Human FREM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FREM2

Target: FREM2 (Fras1 Related Extracellular Matrix Protein 2 (FREM2))

Alternative Name: FREM2 (FREM2 Products)

Synonyms: 6030440P17Rik antibody, 8430406N05Rik antibody, Gm409 antibody, b2b1562Clo antibody, my antibody, ne antibody, nv1 antibody, RGD1566012 antibody, FRAS1 related extracellular matrix protein 2 antibody, Fras1 related extracellular matrix protein 2 antibody, FREM2 antibody, Frem2 antibody

Background: FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.Synonyms: ECM3 homolog, FRAS1-related extracellular matrix protein 2

Gene ID: 341640

NCBI Accession: NP_997244

UniProt: Q5SZK8