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IDH2 antibody (C-Term)
IDH2
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IDH2 Antibody
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Target
See all IDH2 Antibodies
IDH2
(Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
Binding Specificity
All epitopes for IDH2 antibodies
C-Term
Reactivity
All reactivities for IDH2 antibodies
Human, Mouse, Rat
Host
All hosts for IDH2 antibodies
Rabbit
Clonality
All clonalities for IDH2 antibodies
Polyclonal
Conjugate
All conjugates for IDH2 antibodies
This IDH2 antibody is un-conjugated
Application
All applications for IDH2 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
13 amino acid peptide near the carboxy terminus of human IDH1
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Discover our top product IDH2 Primary Antibody
Alternatives
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anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (Middle Region) antibody
IDH2
Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Zebrafish (Danio rerio), Guinea Pig, Saccharomyces cerevisiae
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at -20 °C.
Target Details for IDH2
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Target
IDH2
(Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
Alternative Name
Isocitrate Dehydrogenase / IDH2 (IDH2 Products )
Synonyms
F6P23.14 antibody, F6P23_14 antibody, IDH-II antibody, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 antibody, isocitrate dehydrogenase II antibody, isocitrate dehydrogenase subunit 2 antibody, D2HGA2 antibody, ICD-M antibody, IDH antibody, IDHM antibody, IDP antibody, IDPM antibody, mNADP-IDH antibody, E430004F23 antibody, IDPm antibody, Idh-2 antibody, wu:fb33c06 antibody, wu:fk31e05 antibody, wu:fq43b01 antibody, zgc:55485 antibody, idh2 antibody, IDH2 antibody, isocitrate dehydrogenase subunit 2 antibody, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial antibody, isocitrate dehydrogenase 2 (NADP+), mitochondrial antibody, isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog antibody, isocitrate dehydrogenase [NADP], mitochondrial antibody, IDH2 antibody, Idh2 antibody, idh2.S antibody, idh2 antibody, LOC100441867 antibody
Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.Synonyms: ICD-M, ICDH, IDP, NADP(+)-specific ICDH, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Oxalosuccinate decarboxylase
Gene ID
3418
NCBI Accession
NP_002159
UniProt
P48735
Pathways
Warburg Effect
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