VPS53 antibody (C-Term)

Catalog No. ABIN783564

Product Details anti-VPS53 Antibody

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS53 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects VPS53 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the carboxy terminus of human VPS53

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for VPS53

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Alternative Name: VPS53 (VPS53 Products)

Synonyms: wu:fb77d11 antibody, zgc:103741 antibody, DKFZp469N152 antibody, 2010002A08Rik antibody, 2310040I21Rik antibody, 3100002B05Rik antibody, Hccs1 antibody, HCCS1 antibody, hVps53L antibody, pp13624 antibody, RGD1311391 antibody, VPS53, GARP complex subunit antibody, vacuolar protein sorting 53 homolog (S. cerevisiae) antibody, vacuolar protein sorting 53 antibody, VPS53 GARP complex subunit antibody, VPS53 antibody, vps53 antibody, PAAG_00802 antibody, MCYG_06020 antibody, VDBG_07188 antibody, MGYG_05943 antibody, Vps53 antibody

Background: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.Synonyms: PP13624, Vacuolar protein sorting-associated protein 53 homolog

Gene ID: 55275

NCBI Accession: NP_001121631

UniProt: Q5VIR6