CMYA5 antibody (C-Term)
CMYA5
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
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- Target See all CMYA5 products
- CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CMYA5 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects Myospryn at C-term. SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 18 amino acid peptide near the carboxy terminus of human SPRYD2
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- Target
- CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
- Alternative Name
- Myospryn (CMYA5 Products)
- Background
- SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.Synonyms: C5orf10, CMYA5, Cardiomyopathy-associated protein 5, DTNBP2, Dystrobrevin-binding protein 2, Genethonin-3, SPRY domain-containing protein 2, SPRYD2, TRIM76, Tripartite motif-containing protein 76
- Gene ID
- 202333
- NCBI Accession
- NP_705838
- UniProt
- Q8N3K9
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