CMYA5 antibody (C-Term)

Catalog No. ABIN783522

Product Details anti-CMYA5 Antibody

Target: CMYA5 (Cardiomyopathy Associated 5 (CMYA5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMYA5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Myospryn at C-term. SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human SPRYD2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for CMYA5

Target: CMYA5 (Cardiomyopathy Associated 5 (CMYA5))

Alternative Name: Myospryn (CMYA5 Products)

Synonyms: cmya5l antibody, DKFZp469P2126 antibody, C5orf10 antibody, SPRYD2 antibody, TRIM76 antibody, 2310076E16Rik antibody, 2310076E21Rik antibody, AA420382 antibody, AI504003 antibody, Srfsd antibody, Tims antibody, sr553 antibody, cardiomyopathy associated 5 antibody, CMYA5 antibody, cmya5 antibody, Cmya5 antibody

Background: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.Synonyms: C5orf10, CMYA5, Cardiomyopathy-associated protein 5, DTNBP2, Dystrobrevin-binding protein 2, Genethonin-3, SPRY domain-containing protein 2, SPRYD2, TRIM76, Tripartite motif-containing protein 76

Gene ID: 202333

NCBI Accession: NP_705838

UniProt: Q8N3K9