RASSF10 antibody (N-Term)

Catalog No. ABIN783486

Product Details anti-RASSF10 Antibody

Target: RASSF10 (Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 (RASSF10))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASSF10 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects RASSF10 at N-term. RASSF10 antibody will not cross-react with other RAS association domain-containing family members.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the amino terminus of human RASSF10

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

References for anti-RASSF10 antibody (ABIN783486)

Sherwood, Manbodh, Sheppard, Chalmers: "RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis." in: Molecular biology of the cell, Vol. 19, Issue 4, pp. 1772-82, (2008) (PubMed).

Target Details for RASSF10

Target: RASSF10 (Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 (RASSF10))

Alternative Name: RASSF10 (RASSF10 Products)

Synonyms: 4632411J06Rik antibody, Ras association domain family member 10 antibody, Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 antibody, RASSF10 antibody, Rassf10 antibody

Background: RASSF10 is a member of the N-terminal Ras association domain-containing family of proteins, a family of tumor suppressor genes that are frequently epigenetically inactivated in cancer. These proteins consist of RASSF7-10 and are structurally distinct from RASSF1-6, containing the N-terminal Ras association domain but lacking the Sav/RASSF/Hippo protein interaction domains. While little is known of the function of RASSF10, it is inactivated in both childhood leukemia and gliomas. In secondary glioblastomas, RASSF10 methylation can be used as an independent prognostic associated with worst progression-free survival and overall survival.Synonyms: Ras association domain-containing protein 10

Gene ID: 644943

NCBI Accession: NP_001073990

UniProt: A6NK89