Translin antibody (C-Term)

Catalog No. ABIN783484

Product Details anti-Translin Antibody

Target: Translin (TSN)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Translin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Translin (TSN) at C-term. At least two isoforms of Translin are known to exist, this antibody will detect both.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide near the carboxy terminus of human Translin

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for Translin

Target: Translin (TSN)

Abstract: TSN Products

Synonyms: tsn antibody, MGC52533 antibody, TSN antibody, CG11761 antibody, Dmel\\CG11761 antibody, TB-RBP antibody, BCLF-1 antibody, C3PO antibody, RCHF1 antibody, REHF-1 antibody, TBRBP antibody, TRSLN antibody, 2610034C24Rik antibody, AU040286 antibody, translin L homeolog antibody, translin antibody, haloacid dehalogenase antibody, Translin antibody, tsn.L antibody, TSN antibody, trsn antibody, MMAH_RS03470 antibody, TAGG_RS05275 antibody, Igag_0962 antibody, MFER_RS03645 antibody, DESMU_RS01315 antibody, ARCVE_RS05265 antibody, MZHIL_RS01310 antibody, Tsn antibody

Background: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

Gene ID: 7247

NCBI Accession: NP_004613

UniProt: Q15631