ORMDL1 antibody

Catalog No. ABIN783474

Product Details anti-ORMDL1 Antibody

Target: ORMDL1 (ORM1-Like 1 (ORMDL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORMDL1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects ORMDL1. ORMDL1 antibody is predicted to not cross-react with other ORMDL protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide of human ORMDL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ORMDL1

Target: ORMDL1 (ORM1-Like 1 (ORMDL1))

Alternative Name: ORMDL1 (ORMDL1 Products)

Synonyms: adoplin-1 antibody, C730042F17Rik antibody, ORMDL sphingolipid biosynthesis regulator 1 S homeolog antibody, ORMDL sphingolipid biosynthesis regulator 1 antibody, ORM1-like 1 (S. cerevisiae) antibody, ormdl1.S antibody, ORMDL1 antibody, Ormdl1 antibody

Background: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD) (1-2). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.Synonyms: Adoplin-1, ORM1-like protein 1

Gene ID: 94101

NCBI Accession: NP_001121622

UniProt: Q9P0S3