PRR5L antibody (Center)
PRR5L
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
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- Target See all PRR5L Antibodies
- PRR5L (Proline Rich 5 Like (PRR5L))
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Binding Specificity
- Center
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRR5L antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects PRR5L at Center. At least three isoforms of PRR5L are known to exist, this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 17 amino acid peptide near the center of human PRR5L
- Top Product
- Discover our top product PRR5L Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- Target
- PRR5L (Proline Rich 5 Like (PRR5L))
- Alternative Name
- PRR5L (PRR5L Products)
- Synonyms
- PROTOR2 antibody, 2600010E01Rik antibody, 4833411O04Rik antibody, Protor-2 antibody, Protor2 antibody, RGD1309969 antibody, PRR5L antibody, FLJ14213 antibody, proline rich 5 like antibody, PRR5L antibody, Prr5l antibody, prr5l antibody
- Background
- Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.Synonyms: FLJ14213, PROTOR2, Proline-rich protein 5-like, Protein observed with Rictor-2
- Gene ID
- 79899
- NCBI Accession
- NP_001153639
- UniProt
- Q6MZQ0
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