MYZAP antibody (C-Term)

Catalog No. ABIN783419

Product Details anti-MYZAP Antibody

Target: MYZAP (Myocardial Zonula Adherens Protein (MYZAP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYZAP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects MYOZAP at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human MYOZAP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for MYZAP

Target: MYZAP (Myocardial Zonula Adherens Protein (MYZAP))

Alternative Name: MYOZAP (MYZAP Products)

Synonyms: AA407270 antibody, AV006038 antibody, Gcom1 antibody, Gm640 antibody, Grinl1a7 antibody, Myozap antibody, Myzap antibody, GLURR2 antibody, GRINL1B antibody, GCOM1 antibody, Gup antibody, Gup1 antibody, Gup2 antibody, MYOZAP antibody, myocardial zonula adherens protein antibody, GRINL1B complex locus 2 (pseudogene) antibody, Myzap antibody, GCOM2 antibody, MYZAP antibody

Background: MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein . It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.Synonyms: GCOM1, GRINL1A, Gup, Gup1, Myocardium-enriched zonula occludens-1-interacting protein, glutamate receptor ionotropic N-methyl D-aspartate-like 1A

Gene ID: 145781

NCBI Accession: NP_001018100

UniProt: P0CAP1