MYZAP antibody (C-Term)

Catalog No. ABIN783419

Product Details anti-MYZAP Antibody

Target: MYZAP (Myocardial Zonula Adherens Protein (MYZAP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYZAP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects MYOZAP at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human MYOZAP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for MYZAP

Target: MYZAP (Myocardial Zonula Adherens Protein (MYZAP))

Alternative Name: MYOZAP (MYZAP Products)

Background: MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein . It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.Synonyms: GCOM1, GRINL1A, Gup, Gup1, Myocardium-enriched zonula occludens-1-interacting protein, glutamate receptor ionotropic N-methyl D-aspartate-like 1A

Gene ID: 145781

NCBI Accession: NP_001018100

UniProt: P0CAP1