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FAS antibody (AA 323-327)
FAS
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FAS Antibody
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Target
See all FAS Antibodies
FAS
(TNF Receptor Superfamily, Member 6 (FAS))
Binding Specificity
All epitopes for FAS antibodies
AA 323-327
Reactivity
All reactivities for FAS antibodies
Human
Host
All hosts for FAS antibodies
Rabbit
Clonality
All clonalities for FAS antibodies
Polyclonal
Conjugate
All conjugates for FAS antibodies
This FAS antibody is un-conjugated
Application
All applications for FAS antibodies
Western Blotting (WB)
Sequence
E-N-S-N-F
Specificity
This antibody detects endogenous level of total Fas protein.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Affinity-chromatography using epitope-specific peptide
Immunogen
Peptide sequence around aa.323~327 derived from human Fas .
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store (in aliquots) at -20 °C.
Target Details for FAS
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Target
FAS
(TNF Receptor Superfamily, Member 6 (FAS))
Alternative Name
CD95 / FAS (FAS Products )
Synonyms
ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody
Background
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Molecular Weight
40-50 kDa
Gene ID
355
NCBI Accession
NP_000034
UniProt
P25445
Pathways
p53 Signaling , Apoptosis , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity
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