PNPO antibody (AA 57-261)

Catalog No. ABIN782454

Product Details anti-PNPO Antibody

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Binding Specificity: AA 57-261

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PNPO antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: Teh antibody recognizes human PNPO. Other species not tested.

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human PNPO (57-261aa) purified from E. coli

Clone: AT2C7

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PNPO

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Alternative Name: PNPO (PNPO Products)

Background: PNPO (pyridoxamine 5'-phosphate oxidase) is a 261 amino acid protein belonging to the pyridoxamine 5'-phosphate oxidase family. It is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 (Pyridoxal 5-prime-phosphate or PLP) is vital for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Synonyms: Pyridoxamine-phosphate oxidase, Pyridoxine-5'-phosphate oxidase

Gene ID: 55163

NCBI Accession: NP_060599

UniProt: Q9NVS9