HIPK2 antibody

Catalog No. ABIN781914

Product Details anti-HIPK2 Antibody

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIPK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to HIPK2.

Cross-Reactivity (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: HIPK2 antibody was raised against recombinant protein

Clone: 1F10

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HIPK2

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Alternative Name: HIPK2 (HIPK2 Products)

Background: HIPK2, a nuclear serine/threonine kinase similar to the MNB/DYRK type protein kinases, represses transcription mediated by homeodomain containing transcription factors. HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 to promote p53-dependent gene expression. HIPK2 interacts with various proteins, including members of the p53 family, to regulate cell cycle and apoptosis. Variants of HIPK2 have been observed due to alternative splicing.Synonyms: Homeodomain-interacting protein kinase 2

Gene ID: 28996

NCBI Accession: NP_001106710

UniProt: Q9H2X6

Pathways: Cell Division Cycle