Lambda-IgLC antibody

Catalog No. ABIN775708

Product Details anti-Lambda-IgLC Antibody

Target: Lambda-IgLC (lambda Light Chain (Lambda-IgLC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lambda-IgLC antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: The mouse monoclonal antibody 1-155-2 recognizes lambda light chains (22.5 kDa) of human immunoglobulin.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Human IgA1 lambda myeloma protein

Clone: 1-155-2

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL. Extracellular and intracellular staining.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-Lambda-IgLC antibody (ABIN775708)

Tierens, Holte, Warsame, Ikonomou, Wang, Chan, Delabie: "Low levels of monoclonal small B cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type." in: Haematologica, Vol. 95, Issue 8, pp. 1334-41, (2010) (PubMed).

Bahler, Pindzola, Swerdlow: "Splenic marginal zone lymphomas appear to originate from different B cell types." in: The American journal of pathology, Vol. 161, Issue 1, pp. 81-8, (2002) (PubMed).

Kubagawa, Gathings, Levitt, Kearney, Cooper: "Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence." in: Journal of clinical immunology, Vol. 2, Issue 4, pp. 264-9, (1983) (PubMed).

Target Details for Lambda-IgLC

Target: Lambda-IgLC (lambda Light Chain (Lambda-IgLC))

Alternative Name: Lambda light chains (Lambda-IgLC Products)

Background: Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda, both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.,Immunoglobulin lambda, Igl

Molecular Weight: 22.5 kDa