RND3 antibody (AA 51-150)

Catalog No. ABIN762356

Product Details anti-RND3 Antibody

Target: RND3 (rho Family GTPase 3 (RND3))

Binding Specificity: AA 51-150

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RND3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RND3

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RND3

Target: RND3 (rho Family GTPase 3 (RND3))

Alternative Name: Rnd3 (RND3 Products)

Synonyms: ARHE antibody, Rho8 antibody, RhoE antibody, memB antibody, MGC83857 antibody, 2610017M01Rik antibody, AI661404 antibody, Arhe antibody, Rhoe antibody, RHOE antibody, arhe antibody, id:ibd2712 antibody, id:ibd2919 antibody, rho8 antibody, rnd3 antibody, wu:fc39h07 antibody, zgc:73080 antibody, wu:fd06e12 antibody, zgc:92324 antibody, Rho family GTPase 3 antibody, Rho family GTPase 3 L homeolog antibody, Rho family GTPase 3a antibody, Rho family GTPase 3b antibody, RND3 antibody, rnd3.L antibody, Rnd3 antibody, rnd3a antibody, rnd3b antibody

Background:

Synonyms: ARHE, memB, Rho family GTPase 3, Rho8, RhoE, RND3_HUMAN.

Background: The Rho family of proteins mediates cytoskeleton organization and cell motility responses. This family contains twenty different members divided into five groups, the Rho-like, Rac-like, Cdc42-like, Rnd and RhoBTB subfamilies. Rho proteins have GTPase activity and bind GTP in their active form and GDP in their inactive form. In their active form they interact with downstream proteins. However, the Rnd subfamily of proteins containing the Rnd1, Rnd2 and RhoE(Rnd3), binds GTP but not GDP and has no GTPase activity. While Rho proteins are required for stress fibre formation in cultured fibroblasts, epithelial and endothelial cells, overexpression of Rnd3 or Rnd1 in the same cells may cause an opposite effect (i.e. decrease in stress fibre). Thus, the Rnd3 protein may act as an antagonist for the Rho proteins either by directly binding to Rho or to other downstream proteins.

Gene ID: 390