METTL11A antibody (AA 25-130)

Catalog No. ABIN761786

Product Details anti-METTL11A Antibody

Target: METTL11A (Methyltransferase Like 11A (METTL11A))

Binding Specificity: AA 25-130

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL11A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human METTL11A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for METTL11A

Target: METTL11A (Methyltransferase Like 11A (METTL11A))

Alternative Name: Mettl11a (METTL11A Products)

Synonyms: C9orf32 antibody, C11H9orf32 antibody, METTL11A antibody, NTM1A antibody, AD-003 antibody, HOMT1A antibody, NRMT antibody, 2610205E22Rik antibody, AL033331 antibody, AL033332 antibody, Mettl11a antibody, RGD1306582 antibody, mettl11a antibody, zgc:77488 antibody, N-terminal Xaa-Pro-Lys N-methyltransferase 1 antibody, NTMT1 antibody, Ntmt1 antibody, ntmt1 antibody

Background:

Synonyms: NRMT, NTM1A, AD-003, HOMT1A, C9orf32, METTL11A, N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, N-terminal RCC1 methyltransferase, X-Pro-Lys N-terminal protein methyltransferase 1A, NTMT1, NRMT1

Background: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Gene ID: 28989

UniProt: Q9BV86